张莛蔚

张莛蔚  学术学位硕士生导师

   电话：

    邮件：tingwei_zhang@hospital.cqmu.edu.cn

姓名  张莛蔚

职称职务 副研究员

简介  张莛蔚，女，汉族，1991年7月生，口腔临床医学博士、博士后。

2017年于四川大学华西口腔医学院获博士学位，博士研究生就读期间前往美国南加州大学口腔医学院颅颌面分子生物中心进行联合培养。2018年至2021年于重庆医科大学附属口腔医院博士后流动站从事博士后研究。现任口腔牙周科副研究员，博士研究生导师，兼任中华口腔医学会口腔生物医学专业委员会委员，中华口腔医学会口腔激光委员会青年委员，重庆市口腔生物医学专业委员会委员，重庆市口腔牙周黏膜专业委员会青年委员。近年来，共主持5项国家级及省部级科研项目，发表文章20余篇，获2023年度重庆市科技进步奖二等奖。

联系方式  E-mail tingwei_zhang@hospital.cqmu.edu.cn

教育经历

1. 2014/9-2017/6, 四川大学，口腔医学，博士，导师：王敏

2. 2014/7-2017/11，南加州大学，颅颌面分子生物中心，联合培养博士，合作导师：徐俭

3. 2009/9-2014/6, 四川大学，口腔医学，学士

工作经历

1. 2017/11至今，重庆医科大学，附属口腔医院，主治医师

2. 2018/2-2021/2，重庆医科大学，附属口腔医院，博士后，合作导师：宋锦璘

研究领域

牙周疾病诊断与治疗技术、牙周炎症相关调控分子机制、口肠微生物组致病机制及牙周再生相关研究

成果及奖励

项目

1) 国家自然科学基金面上项目，82170968，PRMT1通过FOXO3/ATG16L1信号轴调控胞外囊泡对伴2型糖尿病牙周炎口腔细菌毒力因子的中和作用机制研究，2022/01-2025/12，52万元

2) 国家自然科学基金青年项目，81800985，Smad6精氨酸甲基化调控LIPUS诱导的PDLSCs外泌体对牙周再生作用机制研究，2019/01-2021/12，21万元

3) 中国博士后科学基金第64批面上项目二等，2018M643427，PRMT1调控DFCs外泌体对牙周再生的作用机制研究，2018/02-2021/02，5万元

4) 重庆市博士后科研项目特别资助三等，X11191，PRMT1调控LIPUS诱导的PDLSCs外泌体对牙周再生作用机制研究，2018/02-2021/02，5万元

5) 重庆市医学青年拔尖人才项目，YXQN202401，2024/07-2027/06，10万元

文章

1) Zhang Y, Zhang Y, Lu M, Yuan X, Li G, Xu L, Zhang T*, & Song J*.  IRE1α regulates macrophage polarization in type 2 diabetic periodontitis through promoting endoplasmic reticulum stress.  Int Immunopharmacol. 2024 Apr 15;133:112056.

2) Lu, M., Zhang, Y., Yuan, X., Zhang, Y., Zhou, M., Zhang, T.*, & Song, J.* (2023). Increased serum α-tocopherol acetate mediated by gut microbiota ameliorates alveolar bone loss through the STAT3 signalling pathway in diabetic periodontitis. Journal of Clinical Periodontology, 1–14.

3) Zhang, Y., Lu, M., Zhang, Y., Yuan, X., Zhou, M., Xu, X., Zhang, T.*, & Song, J.* (2023). Clostridium butyricum MIYAIRI 588 alleviates periodontal bone loss in mice with diabetes mellitus. Annals of the New York Academy of Sciences, 00, 1–17.

4) Lingjie Li,  Lurong Jia,  Siyu Hou,  Tingwei Zhang,  Mengjiao Zhou,  Tao Chen,  Jinlin Song. Temporal and spatial effects on C-reactive protein's regulation of inducible nitric oxide synthase production in periodontal disease. J Periodontol. 2023; 1-13.

5) Xulei Yuan, Fuyuan Zhou, He Wang, Xinxin Xu, Shihan Xu, Chuangwei Zhang, Yanan Zhang, Miao Lu, Yang Zhang, Mengjiao Zhou, Han Li, Ximu Zhang, Tingwei Zhang* & Jinlin Song*. Systemic antibiotics increase microbiota pathogenicity and oral bone loss. Int J Oral Sci 15, 4 (2023).

6) Guangyue Li, Han Qin, Mengjiao Zhou, Tingwei Zhang, Yang Zhang, Huifen Ding, Ling Xu, Jinlin Song,Knockdown of SIRT3 perturbs protective effects of irisin against bone loss in diabetes and periodontitis, Free Radical Biology and Medicine, Volume 200, 2023,Pages 11-25.

7) Li G, Jian Z, Wang H, Xu L, Zhang T, Song J. Irisin Promotes Osteogenesis by Modulating Oxidative Stress and Mitophagy through SIRT3 Signaling under Diabetic Conditions. Oxid Med Cell Longev. 2022 Oct 10;2022:3319056.

8) Mengjiao Zhou, Xiaohui Xu, Jie Li, Jie Zhou, Yao He, Ziqi Chen, Shan Liu, Duanjing Chen, Han Li, Jiao Huang, Gangyi Yang, Tingwei Zhang* and Jinlin Song*, C-reactive protein perturbs alveolar bone homeostasis: An experimental study of periodontitis and diabetes in the rat, Journal of Clinical Periodontology, 2022, 1-152.

9) Tingwei Zhang#, Ziqi Chen#, Mengyuan Zhu, Xuan Jing, Xiaohui Xu, Xulei Yuan, Mengjiao Zhou, Yanan Zhang, Miao Lu, Duanjing Chen, Shihan Xu, Jinlin Song*Extracellular vesicles derived from human dental mesenchymal stem cells stimulated with low-intensity pulsed ultrasound alleviate inflammation-induced bone loss in a mouse model of periodontitis, Genes & Diseases, 2022, doi:10.1016/j.gendis.2022.06.0093.

10) Xuan Jing, Si Wang, Han Tang, Dize Li, Fuyuan Zhou, Liangjing Xin, Qingqing He, Shanshan Hu, Tingwei Zhang*, Tao Chen*, and Jinlin Song*.Dynamically Bioresponsive DNA Hydrogel Incorporated with Dual-Functional Stem Cells from Apical Papilla-Derived Exosomes Promotes Diabetic Bone Regeneration, ACS Applied Materials & Interfaces, 2022, 14 (14)4.

11) Ziqi Chen, Miao Lu, Yanan Zhang, He Wang, Jie Zhou, Mengjiao Zhou, Tingwei Zhang*, Jinlin Song*, Oxidative stress state inhibits exosome secretion of hPDLCs through a specific mechanism mediated by PRMT1, Journal of Periodontal Research, 2022, doi:10.1111/jre.130405.

12) Yongchao Gou, Jingyuan Li, Olan Jackson-Weaver , Jian Wu , Tingwei Zhang, Rahul Gupta, Ihnbae Cho, Thach-Vu Ho, Yibu Chen, Meng Li, Stéphane Richard, Jun Wang, Yang Chai , Jian Xu*, Protein Arginine Methyltransferase PRMT1 Is Essential for Palatogenesis, Journal of Dental Research, 2018, 97(13):1510-15186.

13) Yoko Katsuno#, Jian Qin#, Juan Oses-Prieto, Hongjun Wang, Olan Jackson-Weaver, Tingwei Zhang, Samy Lamouille, Jian Wu, Alma Burlingame, Jian Xu*, Rik Derynck*, Arginine methylation of Smad7 by PRMT1 in TGF-β-induced epithelial-mesenchymal transition and epithelial stem cell generation, Journal of Biological Chemistry, 2018, 293(34):13059-13072 7.

14) Tingwei Zhang, Jian Wu, Nicha Ungvijanpunya, Olan Jackson-Weaver , Yongchao Gou, Jifan Feng, Thach-Vu Ho, Yudao Shen, Liu Jing, Stéphane Richard, Jian Jin, George Hajishengallis, Yang Chai, Jian Xu*, Smad6 Methylation Repress NFkB Activation and Periodontal Inflammation, Journal of Dental Research, 2018, 97(7):810-819 8.

15) Jifan Feng, Junjun Jing, Jingyuan Li, Hu Zhao, Vasu Punj, Tingwei Zhang, Jian Xu, Yang Chai*, BMP signaling orchestrates a transcriptional network to control the fate of mesenchymal stem cells in mice, Development, 2017, 44(14): 2560-25699.

16) Yongchao Gou, Tingwei Zhang, Jian Xu*, Transcription Factors in Craniofacial Development: From Receptor Signaling to Transcriptional and Epigenetic Regulation, Current Topics in development Biology, 2015, 155: 377-41010.

17) Duanjing Chen, Mingli Xiang, Yuanyuan Gong, Ling Xu, Tingwei Zhang, Yao He, Mengjiao Zhou, Liangjing Xin, Jie Li*, Jinling Song*, LIPUS promotes FOXO1 accumulation by downregulating miR-182 to enhance osteogenic differentiation in hPDLCs, Biochimie, 2019, 165：219-228.11.

18) Shihan Xu, Tingwei Zhang, Zhengguo Cao, Wenjie Zhong, Chuangwei Zhang, Han Li, JInlin Song*, Integrin-α9β1 as a Novel Therapeutic Target for Refractory Diseases: Recent Progress and Insights, Frontiers in Immunology, 2021, 12:638400.12.

19)  Xu X, Zhang T, Xia X, Yin Y, Yang S, Ai D, Qin H, Zhou M, Song J. Pyroptosis in periodontitis: From the intricate interaction with apoptosis, NETosis, and necroptosis to the therapeutic prospects. Front Cell Infect Microbiol. 2022 Aug 16;12:953277.13.

20) Wang H, Feng G, Hu B, Tian H, Kuang Y, Zhang T, Song J. Comparison of flash-free and conventional bonding systems: A systematic review and meta-analysis. Angle Orthod. 2022 Jul 14;92(5):691–9.

专利

一种改良的大鼠牙周炎症造模方法，何瑶; 张莛蔚; 宋锦璘; 简子翔; 周梦娇; 张旭阳; 徐铭璐，公开专利号CN113855305A，2021

参译专著

《哥伦布桥治疗方案：即刻负载桥》，人民军医出版社，2017年

奖励

 《适配牙周极端环境的再生材料研发及应用》，重庆市科技进步奖二等奖，2023年度